DEET has been available for more than 50 years in the U.S. and has been studied more extensively than any other repellent ingredient.
It is the most widely used active ingredient in repellents worldwide and is unequalled when it comes to keeping mosquitoes, ticks, and other bugs away.
See NEJM article on Repelling Mosquitoes.
DEET-based repellents are recommended by the Centers for Disease Control and Prevention (CDC), the National Institute for Occupational Safety and Health (NIOSH),
the American Academy of Pediatrics (AAP), and state and local public health officials, among others. AAP says they can be used on all family members over the age of
two (2) months in concentrations up to 30%.